The sons of Anak, also called Anakim, were fearsome giants who lived during the Old Testament times. They lived in Canaan when God sent the Israelites to conquer the land and its inhabitants. There was a saying, a rhetorical question, concerning the sons of Anak. Moses reminded the people of it in Deuteronomy 9:1-2. It was said by many, "Who can stand before the sons of Anak?"
According to Joshua 11:22, the Anakim were nearly wiped out during the war. They were left alive in only three foreign cities: Gaza, Gath, and Ashdod. God can stand before the sons of Anak. Every Anakim in Canaan fell before Him. Throughout history, there have been many great and powerful people, but God surpasses them all.
Revelation 6:12ff tells how God's enemies ran in fear from the wrath of the Lamb, Jesus. A familiar question is then spoken, but not about the Anakim. Concerning the wrath of the Lamb erupting onto all these wicked ones, verse seventeen asks rhetorically, "…and who is able to stand?" The question that had been only hyperbolically spoken of the Anakim now sounds forth the truth of God's wrath: no one can endure it.
On the last day, the day of judgment, God will honor those who have honored Him and will return wrath on those who have rebuffed Him. Choose your enemies and allies wisely. There is only One before whose wrath none can stand. He resides in Heaven, and His patience, while long, is not infinite (2 Peter 3:9-10).